Search results for "Nicotinic Acetylcholine Receptors"

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Association of Common Polymorphisms in the Nicotinic Acetylcholine Receptor Alpha4 Subunit Gene with an Electrophysiological Endophenotype in a Large…

2016

PLoS one 11(4), e0152984 (2016). doi:10.1371/journal.pone.0152984

Male0301 basic medicineNicotinic Acetylcholine ReceptorsPhysiologyEvent-Related Potentialslcsh:MedicineReceptors NicotinicElectroencephalography600 Technik Medizin angewandte Wissenschaften::610 Medizin und GesundheitBiochemistryExonCognitionMathematical and Statistical Techniques0302 clinical medicineMedizinische FakultätGermanyMedicine and Health Scienceslcsh:ScienceCerebral CortexClinical NeurophysiologyGeneticsBrain MappingN100education.field_of_studyMultidisciplinarymedicine.diagnostic_testSmokingBrainElectroencephalographyTobacco Use DisorderTemporal LobeFrontal LobeElectrophysiologyNicotinic acetylcholine receptorBioassays and Physiological AnalysisBrain ElectrophysiologyPhysical SciencesRegression AnalysisFemaleAnatomyFunction and Dysfunction of the Nervous SystemStatistics (Mathematics)Research ArticleSignal TransductionAdultTransmembrane ReceptorsImaging TechniquesEndophenotypesCognitive NeurosciencePopulation610NeurophysiologyNeuroimagingSingle-nucleotide polymorphism-Linear Regression AnalysisBiologyResearch and Analysis MethodsPolymorphism Single Nucleotide03 medical and health sciencesDiagnostic MedicineEvent-related potentialReaction TimemedicineHumansddc:610Statistical MethodseducationElectrophysiological Techniqueslcsh:RBiology and Life SciencesProteinsCell BiologyElectrophysiological Phenomena030104 developmental biologyAcetylcholine ReceptorsEndophenotypeCognitive Sciencelcsh:QMathematics030217 neurology & neurosurgeryNeuroscience
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Conformational changes in acetylcholine binding protein investigated by temperature accelerated molecular dynamics.

2014

Despite the large number of studies available on nicotinic acetylcholine receptors, a complete account of the mechanistic aspects of their gating transition in response to ligand binding still remains elusive. As a first step toward dissecting the transition mechanism by accelerated sampling techniques, we study the ligand-induced conformational changes of the acetylcholine binding protein (AChBP), a widely accepted model for the full receptor extracellular domain. Using unbiased Molecular Dynamics (MD) and Temperature Accelerated Molecular Dynamics (TAMD) simulations we investigate the AChBP transition between the apo and the agonist-bound state. In long standard MD simulations, both confo…

Nicotinic Acetylcholine ReceptorsProtein ConformationGatingMolecular DynamicsLigandsBiochemistryBiophysics SimulationsIon ChannelsMolecular dynamicsAcetylcholine bindingComputational ChemistryBiochemical SimulationsNicotinic AgonistsBiomacromolecule-Ligand InteractionsBiochemistry SimulationsMultidisciplinaryHydrogen bondChemistryPhysicsQTemperatureRLigand (biochemistry)nicotinic receptor molecular dynamics tamd acethylcholine binding proteinChemistryNicotinic agonistBiochemistryMedicineBiophysic Al SimulationsResearch ArticleProtein BindingProtein subunitScienceBiophysicsMolecular Dynamics SimulationProtein ChemistryStatistical MechanicsChemical BiologyAnimalsBiologyAcetylcholine receptorBinding SitesProteinsComputational BiologyHydrogen BondingSettore FIS/07 - Fisica Applicata(Beni Culturali Ambientali Biol.e Medicin)Protein SubunitsMolluscaAcetylcholine ReceptorsBiophysicsLobelineCarrier ProteinsPLoS ONE
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